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Oh My, how I love science right now!!! After reading this article, you´ll understand my excitement ... :)
NMN - I believe, will intrigue every single youth/health seeker.
Aging - the process that most people, would like to slow down or even reverse. Because of the science, now, this can be possible for anyone! Aging can be defined as the sum of all the mechanisms that alter the functions of a living thing, prevents it from maintaining physiological balance and eventually leads to the death of said organism. This unpleasant process is complex, gradual and depends on many biological factors; can be amplified by external factors throughout a lifetime (pollution, food, smoking…)
Today, scientists believe that it’s possible to stop people from growing old quickly and help them live with good health well into their 120s or 110s. They say- NEW ANTI-AGING ERA is here!!!!
NMN - THE BIGGEST DISCOVERY
NMN is most notable for its effectiveness in restoring NAD+ and combatting the symptoms of aging, but recent lab tests and research suggests it can also help with other important functions.
* Nicotinamide Adenine Dinucleotide (NAD+) is essential for health and longevity – promotes brain health and cellular regeneration while reducing inflammation. As we age, our levels of NAD+ decrease.
(Chronic inflammation is one of the main underlying causes of aging. It is low intensity inflammation that you cannot see happening. This kind of inflammation slowly ages your skin. Chronic inflammation can last for days to a lifetime.)
SO WHAT IS NMN?
NMN is a Nicotinamide Mononucleotide containing three groups: a nicotinamide group, a ribose group, and a phosphate group. It is the direct progenitor of the essential molecule nicotinamide adenine dinucleotide (NAD+), a coenzyme that is integral for different cellular functions. These coenzymes act as an ‘helper' because they help the enzymes perform different biochemical and cellular reactions to maintain healthy bodily functions.
NMN is a cutting-edge vitamin B3 derivative that boosts NAD+ levels and mitigates many factors of aging. Unlike other supplements, NMN enters the bloodstream directly and activates within 15 minutes with some potential anti-aging benefits include:
- Increased Skin Elasticity - Improved Bone Density - Boosted Muscle Function - Fewer Wrinkles DNA Repair
- Improves the Brain
- Gives mental Clarity
- Promotes Longevity
- Improve Metabolic Markers
- Improve Physical Endurance
- Improves The Neurological Function of the Body
*In lab tests with mice, NMN has been noted to improve eyesight and hearing.
In other words, NMN slows down/ even reverses practically all kind of aging.
In numerous mouse models of disease and aging, NMN has demonstrated a wide array of remarkable effects, benefitting conditions ranging from diabetes to Alzheimer’s disease to ischemia. NMN has been able to suppress age-associated weight gain, enhance energy metabolism and physical activity, improve insulin sensitivity, improve eye function, improve mitochondrial metabolism and prevent age-linked changes in gene expression.
NMN can improve adult metabolism, rendering it more like that of someone ten or twenty years younger!!!
David Sinclair, Harvard University’s noted anti-aging researcher (he and his team discovered NMN), is taking NMN himself; he has said his lipid profile has improved dramatically and he feels more energetic and that his blood markers, at nearly 60 years old, are closer to those of a 31-year-old.
"NAD+ is the closest we’ve gotten to a fountain of youth"
- Dr. David Sinclair, TIME Magazine
David Sinclair uncovered the power of a chemical called resveratrol. He also worked on proteins called Sirtuins as well as NAD+ .
Dr. Sinclair has shown that SIRT1 (Sirtuins are a group of proteins that regulate cellular health and homeostasis, support energy metabolism, improve brain health, help cellular repair, and support healthy aging) levels can be raised by increasing NAD levels through supplementation with NMN and Resveratrol.
| THIS LITERALLY TURNS BACK THE `CELLULAR CLOCK" ON AGING’! Now, you understand my excitement, I think :D...
Well, lets dig little bit deeper in all this science discovery …
! NMN to bring us all the powerful benefits at it best, must be taken together with Resveratrol!
RESVERATROL BENEFITS
The growing body of knowledge in academic literature regarding resveratrol is enormous and its documented health effects are indisputable at this point. In addition to improvements in cardiovascular health, resveratrol has been shown to improve metabolic and neurological health, increase endurance, extend lifespan in healthy animals, lower blood pressure, prevent osteoporosis, and showcase promising anti-cancer properties. Furthermore, resveratrol acts like a calorie restriction mimetic. This means that it induces the same biochemical effects in the cells as would starvation or fasting would do. Multiple studies have shown that autophagy is induced with resveratrol. About fasting and autophagy I´ll soon write separated post, because it´s one
more important part in an anti-aging journey.
SIRTUINS, RESVERATROL AND NMN ARE ALL INTERCONNECTED, LOOKING TO STOP - EVEN REVERSE - AGING...
WHY NMN + RESVERATROL?
NMN and Resveratrol are molecules which essentially mimic the effects of the sirtuin genes:
“You can think of resveratrol as the accelerator pedal for the sirtuin genes, and NMN as the fuel” “Resveratrol steps on the accelerator pedal of the sirtuin enzymes”, says Dr. David Sinclair.
So we need the fuel (NMN) for resveratrol to work. Related to resveratrol, NMN is supposedly a much better form of resveratrol. It’s an NAD+ precursor and booster. As people age, they could maintain healthy levels of NAD+ by taking NMN supplements.
NMN + Resveratrol supplements provide healthy enzymes that combat the aging process, and hence it acts as an anti-aging agent.
HOW TO TAKE NMN + RESVERATROL?
It is best to take NMN first thing in the morning. For increased effectiveness, NMN should be kept refrigerated and consumed together with Resveratrol. You can have breakfast directly after consuming NMN.
NMN comes in the form of powder or capsules and the daily dose needed for great benefits are 500mg - 1000mg per day. Resveratrol - 600mg - 1000mg. As said, must be taken together.
P.S. Remember, that all this supplementation still needs to be complimented with healthy lifestyle (exercise, healthy eating, drinking plenty of water and calm/stressless mind!)
*What about side effects?
NMN has no proven adverse side effects. According to recent research by Mills et al., NMN exhibits “no obvious toxicity or deleterious effects.”
Fascinating Fountain of Youth… Don’t you think? To scientists, the ultimate goal is to develop treatments that slow, stop or even reverse aging — for people to live a long and healthy life. Amazingly this is happening….
As you can see, consumption of NMN supplements daily provide unlimited health benefits for you to improve your quality of life. I´m planning to start my NMN journey in a month or so ( as I said, I’m testing other beauty supplement at a time) … of course, I´ll let you know how it’ll go…
This marvelous anti-aging discovery unfortunately is little bit pricy, and as I´m still searching the best option for me. I’m seeing that many NMN supplements comes with low dose of NMN... so be careful to check well how much NMN each brand is offering.
OTHER SUPPLEMENTS TO CONSIDER INTAKEN ACCORDING TO DR. DAVID SINCLAIR
- Vitamin D3 + K2 +Mg ( couldn’t agree more…I think it’s a must after 40! Vitamin D supports bone health, heart and immune function, protecting against cancer. Vitamin D3 ensures absorption of calcium while vitamin K2 directs calcium to the proper location in the body, preventing it from depositing where it shouldn't, such as in the arteries, organs and joints. Mg makes sure everything is going in the right places.)
- Quercetin (The most abundant dietary flavonoid. It’s been linked to improved exercise performance and reduced inflammation, blood pressure, and blood sugar levels. Plus, it may have brain-protective, anti-allergy, and anticancer properties.This one I’m testing on me already about 2 months now… so far so good!… it should be taken for 7 days and then 3 weeks pause)
- Metformin read more HERE
LITTLE BIT MORE SCIENTIFICALLY:The Science Behind NMN–A Stable, Reliable NAD+Activator and Anti-Aging Molecule
By middle age, our NAD+ levels have plummeted to half that of our youth. Numerous studies have demonstrated that boosting NAD+ levels increases insulin sensitivity, reverses mitochondrial dysfunction, and extends lifespan. NAD+ levels can be increased by activating enzymes that stimulate synthesis of NAD+, by inhibiting an enzyme (CD38) that degrades NAD+, and by supplementing with NAD precursors, including nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN).
Taken orally, NMN is rapidly absorbed and converted to NAD+. In numerous studies, supplementation with NMN has increased NAD+ biosynthesis, suppressed age-related adipose tissue inflammation, enhanced insulin secretion and insulin action, improved mitochondrial function, improved neuronal function in the brain, and more. Here, we look at the science behind NMN, its stability, possible pharmacokinetics, transport, function, and ability to induce biosynthesis of NAD+. Supplementing NMN may be an effective nutraceutical anti-aging intervention, with beneficial effects on a wide array of physiological functions.
A veritable symphony of interlocking transformations allows NAD+ to be both synthesized and regulated in the body. It is well known that vitamin B3 is a building block for Nicotinamide adenine dinucleotide (NAD+). It is also widely recognized that NMN is a potent precursor for NAD+. Though NMN is naturally found in small amounts in fruits and vegetables such as avocados, broccoli, cabbage, edamame, shrimp and cucumbers...but only tiny amounts of it.
UPDATE!
It`s been a while since I wrote the article above ... Now its 2022 after a few days already and I´m super happy to say that I have found the most perfect NMN I could wish for ... AGE SCIENCE is German brand/lab that with all the possible transparency offers purest, high quality NMN.
*Age Science is first NMN supplier that specializes in NMN powder in Germany and Europe
*With the latest scientific findings in age research, Age Science comes with NMN of the best quality at fair prices available to all users.
* All Age Science NMN purity ≥ 99% (pharmaceutical quality).
* GMO-free, gluten-free and soy-free. No artificial colors, flavors or preservatives | 100% NMN nicotinamide mononucleotide.
*Age Science is transparent and honest brand (see all the possible details on their website)
*Age Science works with the world's best NMN manufacturers
*Worldwide delivery.
*Free EU shipping.
*...and they have some amazing thing... more you buy, more you gain in a product quantity.
And here I’m, feeling so happy, that I can bring “closer” to all of you the NMN that is pure, high quality and for fair price.
I’m planning to start my NMN journey from 2nd January …
New Year, New Life!!!
I’ll test on me for one year this groundbreaking scientific achievement… of course, I’ll let you all know how it will go during and after.
📌 if you choose to look for other brands that offer NMN products, you should be extremely careful. The following information should be observed when purchasing an NMN: HERE
//I am healthy anti-aging enthusiast, not a nutritionist nor dermatologist. Therefore, you might want to clarify some things with a specialist first, especially if you have a specific health or skin problem.
some sources:
